It is in Beyoglu, Karakurum Street in Tarlabasi. It is the only church in Istanbul commissioned by Syriac minority. Syriacs either borrow the other churches they use from other religious sects or they hire them.
Saint Mary Church was built in 1960 by the stones brought from Mardin, the center of Syriac sect in Turkey.
It is a big stone building. Apart from the church, it has sections such as administrative building and school.